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Titel:

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.

Dokumenttyp:
journal article
Autor(en):
Rokavec, Matjaz, M; Oner, Meryem Gülfem, MG; Li, Huihui, H; Jackstadt, Rene, R; Jiang, Longchang, L; Lodygin, Dmitri, D; Kaller, Markus, M; Horst, David, D; Ziegler, Paul K, PK; Schwitalla, Sarah, S; Slotta-Huspenina, Julia, J; Bader, Franz G, FG; Greten, Florian R, FR; Hermeking, Heiko, H
Abstract:
Members of the miR-34 family are induced by the tumor suppressor p53 and are known to inhibit epithelial-to-mesenchymal transition (EMT) and therefore presumably suppress the early phases of metastasis. Here, we determined that exposure of human colorectal cancer (CRC) cells to the cytokine IL-6 activates the oncogenic STAT3 transcription factor, which directly represses the MIR34A gene via a conserved STAT3-binding site in the first intron. Repression of MIR34A was required for IL-6-induced EMT...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2014
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24642471
Print-ISSN:
0021-9738
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie
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