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Titel:

Activation of the PI3K/AKT pathway correlates with prognosis in stage II colon cancer.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Malinowsky, K; Nitsche, U; Janssen, K-P; Bader, F G; Späth, C; Drecoll, E; Keller, G; Höfler, H; Slotta-Huspenina, J; Becker, K-F
Abstract:
Patients with UICC/AJCC stage II colon cancer have a high 5-year overall survival rate after surgery. Nevertheless, a significant subgroup of patients develops tumour recurrence. Currently, there are no clinically established biomarkers available to identify this patient group. We applied reverse-phase protein arrays (RPPA) for phosphatidylinositide-3-kinase pathway activation mapping to stratify patients according to their risk of tumour recurrence after surgery.Full-length proteins were extrac...     »
Zeitschriftentitel:
Br J Cancer
Jahr:
2014
Band / Volume:
110
Heft / Issue:
8
Seitenangaben Beitrag:
2081-9
Sprache:
eng
Volltext / DOI:
doi:10.1038/bjc.2014.100
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24619078
Print-ISSN:
0007-0920
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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