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Titel:

Multicenter Immunohistochemical ALK-Testing of Non-Small-Cell Lung Cancer Shows High Concordance after Harmonization of Techniques and Interpretation Criteria.

Dokumenttyp:
Journal Article
Autor(en):
von Laffert, Maximilian; Warth, Arne; Penzel, Roland; Schirmacher, Peter; Kerr, Keith M; Elmberger, Göran; Schildhaus, Hans-Ulrich; Büttner, Reinhard; López-Ríos, Fernando; Reu, Simone; Kirchner, Thomas; Pauwels, Patrick; Specht, Katja; Drecoll, Enken; Höfler, Heinz; Aust, Daniela; Baretton, Gustavo; Bubendorf, Lukas; Stallmann, Sonja; Fisseler-Eckhoff, Annette; Soltermann, Alex; Tischler, Verena; Moch, Holger; Penault-Llorca, Frederique; Hager, Hendrik; Schäper, Frank; Lenze, Dido; Hummel, Mich...     »
Abstract:
Detection of anaplastic lymphoma kinase (ALK)-gene rearrangements in non-small-cell lung cancer (NSCLC) is mainly performed by fluorescence in-situ hybridization (FISH). The question was raised if FISH might be replaced by immunohistochemistry (IHC) in a reliable and reproducible manner across different laboratories.After calibration of the staining instruments and training of the observers to binary interpretation (positive versus negative), 15 NSCLC were independently tested for ALK protein ex...     »
Zeitschriftentitel:
J Thorac Oncol
Jahr:
2014
Band / Volume:
9
Heft / Issue:
11
Seitenangaben Beitrag:
1685-1692
Sprache:
eng
Volltext / DOI:
doi:10.1097/JTO.0000000000000332
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25436802
Print-ISSN:
1556-0864
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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