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Titel:

Acinar cell carcinomas of the pancreas: a molecular analysis in a series of 57 cases.

Dokumenttyp:
Journal Article
Autor(en):
Bergmann, Frank; Aulmann, Sebastian; Sipos, Bence; Kloor, Matthias; von Heydebreck, Anja; Schweipert, Johannes; Harjung, Andreas; Mayer, Philipp; Hartwig, Werner; Moldenhauer, Gerhard; Capper, David; Dyckhoff, Gerhard; Freier, Kolja; Herpel, Esther; Schleider, Anja; Schirmacher, Peter; Mechtersheimer, Gunhild; Klöppel, Günter; Bläker, Hendrik
Abstract:
Pancreatic acinar cell carcinomas (PACs) are rare but are distinct aggressive neoplasms that phenotypically differ from pancreatic ductal adenocarcinomas (PDACs) and pancreatic neuroendocrine neoplasms (PNENs). Despite recent work on the genetic changes of PACs, their molecular pathogenesis is still poorly understood. In this study, we focus on a comparative genomic hybridization analysis. Based on frequent chromosomal imbalances, the involvement of DCC and c-MYC in the pathogenesis of PACs is f...     »
Zeitschriftentitel:
Virchows Arch
Jahr:
2014
Band / Volume:
465
Heft / Issue:
6
Seitenangaben Beitrag:
661-72
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00428-014-1657-8
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25298229
Print-ISSN:
0945-6317
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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