Influence of high-flux hemodialysis and hemodiafiltration on serum C-terminal agrin fragment levels in end-stage renal disease patients.

Steubl, Dominik; Hettwer, Stefan; Dahinden, Pius; Wolf, Petra; Luppa, Peter; Wagner, Carsten A; Küchle, Claudius; Schmaderer, Christoph; Renders, Lutz; Heemann, Uwe; Roos, Marcel

doi:10.1016/j.trsl.2014.05.005

2014

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Title:: Influence of high-flux hemodialysis and hemodiafiltration on serum C-terminal agrin fragment levels in end-stage renal disease patients.
Document type:: Journal Article; Article
Author(s):: Steubl, Dominik; Hettwer, Stefan; Dahinden, Pius; Wolf, Petra; Luppa, Peter; Wagner, Carsten A; Küchle, Claudius; Schmaderer, Christoph; Renders, Lutz; Heemann, Uwe; Roos, Marcel
Abstract:: C-terminal agrin fragment (CAF, 22 kDa) has been shown to be a promising new rapid biomarker for kidney function. This study evaluated the influence of hemodialysis (HD) and hemodiafiltration (HDF) treatment on serum CAF concentrations in patients with end-stage renal disease (ESRD). A total of 36 patients with ESRD undergoing chronic HD/HDF treatment were enrolled (21 high-flux-HD/Fx60 membrane, 7 high-flux-HD/Elisio19H membrane, and 8 HDF/Elisio19H membrane). On a midweek session, blood samples were obtained before, at halftime, and post-treatment. Dialysate samples were obtained 4 times during treatment. Serum and dialysate CAF, cystatin C, urea, and creatinine concentrations were measured. Reduction ratios (RRs), total solute removal, overall dialytic clearance, and instantaneous dialytic clearance at halftime were calculated and compared. Although HD/Elisio19H and HDF/Elisio19H treatments significantly reduced CAF concentrations (RR 46.6 ± 9.1% and 57.6 ± 11.7%, respectively, P = 0.018 and P = 0.001), HD/Fx60 treatment did not remove CAF from serum (RR 2.4 ± 15.4%, P = 0.25), there was no relevant CAF detection in dialysate. In the HD/Fx60 group, the RR of CAF was significantly lower compared with cystatin C, urea, and creatinine, in which significant removal was detected (37.9 ± 14.8%, 65.0 ± 10.7%, and 56.0 ± 9.8%, respectively, P < 0.001). CAF is a new biomarker for kidney function whose serum concentration is not influenced by conventional high-flux HD using Fx60 membrane. It might therefore represent a promising dialysis-independent biomarker for evaluation of kidney function, for example, in acute kidney failure.
Journal title abbreviation:: Transl Res
Year:: 2014
Journal volume:: 164
Journal issue:: 5
Pages contribution:: 392-9
Language:: eng
Fulltext / DOI:: doi:10.1016/j.trsl.2014.05.005
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/24907476
Print-ISSN:: 1931-5244
TUM Institution:: Fachgebiet Nephrologie (Prof. Heemann); Institut für Klinische Chemie und Pathobiochemie; Institut für Medizinische Statistik und Epidemiologie
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland)2014

mediaTUM Gesamtbestand Hochschulbibliographie 2014 Fakultäten Medizin Institut für Klinische Chemie und Pathobiochemie

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für KI und Informatik in der Medizin (Prof. Rückert)2014

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid)Abteilung für Nephrologie (Prof. Heemann)Professur für Nephrologie (Prof. Heemann)2014

mediaTUM Gesamtbestand Hochschulbibliographie 2014 Fakultäten Medizin Institut für Medizinische Statistik und Epidemiologie