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Titel:

MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Ganesan, Jayavarshni; Ramanujam, Deepak; Sassi, Yassine; Ahles, Andrea; Jentzsch, Claudia; Werfel, Stanislas; Leierseder, Simon; Loyer, Xavier; Giacca, Mauro; Zentilin, Lorena; Thum, Thomas; Laggerbauer, Bernhard; Engelhardt, Stefan
Abstract:
Several microRNAs (miRs) have been shown to regulate gene expression in the heart, and dysregulation of their expression has been linked to cardiac disease. miR-378 is strongly expressed in the mammalian heart but so far has been studied predominantly in cancer, in which it regulates cell survival and tumor growth.Here, we report tight control of cardiomyocyte hypertrophy through miR-378. In isolated primary cardiomyocytes, miR-378 was found to be both necessary and sufficient to repress cardiom...     »
Zeitschriftentitel:
Circulation
Jahr:
2013
Band / Volume:
127
Heft / Issue:
21
Seitenangaben Beitrag:
2097-106
Sprache:
eng
Volltext / DOI:
doi:10.1161/CIRCULATIONAHA.112.000882
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23625957
Print-ISSN:
0009-7322
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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