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Title:

Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Hampl, Veronika; Martin, Claudia; Aigner, Achim; Hoebel, Sabrina; Singer, Stephan; Frank, Natalie; Sarikas, Antonio; Ebert, Oliver; Prywes, Ron; Gudermann, Thomas; Muehlich, Susanne
Abstract:
Megakaryoblastic leukaemia 1 and 2 (MKL1/2) are coactivators of the transcription factor serum response factor (SRF). Here, we provide evidence that depletion of MKL1 and 2 abolishes hepatocellular carcinoma (HCC) xenograft growth. Loss of the tumour suppressor deleted in liver cancer 1 (DLC1) and the subsequent activation of RhoA were prerequisites for MKL1/2 knockdown-mediated growth arrest. We identified oncogene-induced senescence as the molecular mechanism underlying the anti-proliferative...     »
Journal title abbreviation:
EMBO Mol Med
Year:
2013
Journal volume:
5
Journal issue:
9
Pages contribution:
1367-82
Language:
eng
Fulltext / DOI:
doi:10.1002/emmm.201202406
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23853104
Print-ISSN:
1757-4676
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Pharmakologie und Toxikologie
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