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Title:

Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes.

Document type:
Journal Article
Author(s):
Ding, Jie; Domes, Katrin; Hofmann, Franz; Wegener, Jörg W
Abstract:
Cardiac CaV1.2 channels play a critical role in cardiac function. It has been proposed that the carboxyl-terminal intracellular tail of the CaV1.2 channel is the target of Ca(2+)-dependent and Ca(2+)-independent regulation of the channel. Recent studies on C-terminal truncated forms of the CaV1.2 channel reported neonatal death, reduced CaV1.2 current, and failure of ?-adrenergic stimulation of these channels in ventricular cardiomyocytes (CMs). Here, we used atrial CMs at embryonic day 18.5 tha...     »
Journal title abbreviation:
Pflugers Arch
Year:
2013
Journal volume:
465
Journal issue:
7
Pages contribution:
955-64
Language:
eng
Fulltext / DOI:
doi:10.1007/s00424-012-1212-x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23338940
Print-ISSN:
0031-6768
TUM Institution:
Institut für Pharmakologie und Toxikologie
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