User: Guest  Login
More Searchfields
Simple search
Title:

A novel CXCL10-based GPI-anchored fusion protein as adjuvant in NK-based tumor therapy.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Muenchmeier, Niklas; Boecker, Sophia; Bankel, Lorenz; Hinz, Laura; Rieth, Nicole; Lapa, Constantin; Mendler, Anna N; Noessner, Elfriede; Mocikat, Ralph; Nelson, Peter J
Abstract:
Cellular therapy is a promising therapeutic strategy for malignant diseases. The efficacy of this therapy can be limited by poor infiltration of the tumor by immune effector cells. In particular, NK cell infiltration is often reduced relative to T cells. A novel class of fusion proteins was designed to enhance the recruitment of specific leukocyte subsets based on their expression of a given chemokine receptor. The proteins are composed of an N-terminal chemokine head, the mucin domain taken fro...     »
Journal title abbreviation:
PLoS ONE
Year:
2013
Journal volume:
8
Journal issue:
8
Pages contribution:
e72749
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0072749
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24023642
Print-ISSN:
1932-6203
TUM Institution:
Institut für Pharmakologie und Toxikologie
 BibTeX