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Title:

microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Gurha, Priyatansh; Wang, Tiannan; Larimore, Ashley H; Sassi, Yassine; Abreu-Goodger, Cei; Ramirez, Maricela O; Reddy, Anilkumar K; Engelhardt, Stefan; Taffet, George E; Wehrens, Xander H T; Entman, Mark L; Rodriguez, Antony
Abstract:
Increasing evidence suggests that microRNAs are intimately involved in the pathophysiology of heart failure. MicroRNA-22 (miR-22) is a muscle-enriched miRNA required for optimum cardiac gene transcription and adaptation to hemodynamic stress by pressure overload in mice. Recent evidence also suggests that miR-22 induces hypertrophic growth and it is oftentimes upregulated in end stage heart failure. However the scope of mRNA targets and networks of miR-22 in the heart failure remained unclear. W...     »
Journal title abbreviation:
PLoS ONE
Year:
2013
Journal volume:
8
Journal issue:
9
Pages contribution:
e75882
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0075882
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24086656
Print-ISSN:
1932-6203
TUM Institution:
Institut für Pharmakologie und Toxikologie
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