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Title:

The human transcriptome is enriched for miRNA-binding sites located in cooperativity-permitting distance.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Rinck, Andrea; Preusse, Martin; Laggerbauer, Bernhard; Lickert, Heiko; Engelhardt, Stefan; Theis, Fabian J
Abstract:
MiRNAs are short, non-coding RNAs that regulate gene expression post-transcriptionally through specific binding to mRNA. Deregulation of miRNAs is associated with various diseases and interference with miRNA function has proven therapeutic potential. Most mRNAs are thought to be regulated by multiple miRNAs and there is some evidence that such joint activity is enhanced if a short distance between sites allows for cooperative binding. Until now, however, the concept of cooperativity among miRNAs...     »
Journal title abbreviation:
RNA Biol
Year:
2013
Journal volume:
10
Journal issue:
7
Pages contribution:
1125-35
Language:
eng
Fulltext / DOI:
doi:10.4161/rna.24955
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23696004
Print-ISSN:
1547-6286
TUM Institution:
Institut für Pharmakologie und Toxikologie
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