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Title:

MiR-223 is dispensable for platelet production and function in mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Leierseder, Simon; Petzold, Tobias; Zhang, Lin; Loyer, Xavier; Massberg, Steffen; Engelhardt, Stefan
Abstract:
MicroRNAs (miRNAs) are key physiological regulators in multiple cell types. Here, we assessed platelet production and function in mice deficient in miR-223, one of the most abundantly expressed miRNAs in platelets and megakaryocytes. We found platelet number, size, life-span as well as surface expression of platelet adhesion receptors to be unchanged in miR-223-deficient mice. Likewise, loss of miR-223 did not affect platelet activation, adhesion and aggregation and also had no effect on bleedin...     »
Journal title abbreviation:
Thromb Haemost
Year:
2013
Journal volume:
110
Journal issue:
6
Pages contribution:
1207-14
Language:
eng
Fulltext / DOI:
doi:10.1160/TH13-07-0623
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24067995
Print-ISSN:
0340-6245
TUM Institution:
Institut für Pharmakologie und Toxikologie
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