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Title:

Thrombocytosis as a response to high interleukin-6 levels in cGMP-dependent protein kinase I mutant mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Zhang, Lin; Lukowski, Robert; Gaertner, Florian; Lorenz, Michael; Legate, Kyle R; Domes, Katrin; Angermeier, Elisabeth; Hofmann, Franz; Massberg, Steffen
Abstract:
The purpose of this study was to investigate the influence of cGMP-dependent kinase I (cGKI) on platelet production.We used hematology analyser to measure platelet counts in conventional cGKI-null mutants (cGKI(L1/L1)), gene-targeted cGKI?/? rescue mice (referred to as cGKI-smooth muscle [SM]) in which cGKI expression is specifically restored only in SM, platelet factor 4-Cre(tg/+); cGKI(L2/L2) mice in which the cGKI protein was specifically deleted in the megakaryocyte/platelet lineage and cGK...     »
Journal title abbreviation:
Arterioscler Thromb Vasc Biol
Year:
2013
Journal volume:
33
Journal issue:
8
Pages contribution:
1820-8
Language:
eng
Fulltext / DOI:
doi:10.1161/ATVBAHA.113.301507
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23788765
Print-ISSN:
1079-5642
TUM Institution:
Institut für Pharmakologie und Toxikologie
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