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Titel:

MiR-223 is dispensable for platelet production and function in mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Leierseder, Simon; Petzold, Tobias; Zhang, Lin; Loyer, Xavier; Massberg, Steffen; Engelhardt, Stefan
Abstract:
MicroRNAs (miRNAs) are key physiological regulators in multiple cell types. Here, we assessed platelet production and function in mice deficient in miR-223, one of the most abundantly expressed miRNAs in platelets and megakaryocytes. We found platelet number, size, life-span as well as surface expression of platelet adhesion receptors to be unchanged in miR-223-deficient mice. Likewise, loss of miR-223 did not affect platelet activation, adhesion and aggregation and also had no effect on bleedin...     »
Zeitschriftentitel:
Thromb Haemost
Jahr:
2013
Band / Volume:
110
Heft / Issue:
6
Seitenangaben Beitrag:
1207-14
Sprache:
eng
Volltext / DOI:
doi:10.1160/TH13-07-0623
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24067995
Print-ISSN:
0340-6245
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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