Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease.

Becker-Grünig, T; Klose, H; Ehlken, N; Lichtblau, M; Nagel, C; Fischer, C; Gorenflo, M; Tiede, H; Schranz, D; Hager, A; Kaemmerer, H; Miera, O; Ulrich, S; Speich, R; Uiker, S; Grünig, E

doi:10.1016/j.ijcard.2012.09.036

2013

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Title:: Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease.
Document type:: Journal Article; Research Support, Non-U.S. Gov't
Author(s):: Becker-Grünig, T; Klose, H; Ehlken, N; Lichtblau, M; Nagel, C; Fischer, C; Gorenflo, M; Tiede, H; Schranz, D; Hager, A; Kaemmerer, H; Miera, O; Ulrich, S; Speich, R; Uiker, S; Grünig, E
Abstract:: The objective of this prospective study was to assess the efficacy of exercise training as add-on to medical therapy in patients with congenital heart disease associated pulmonary arterial hypertension (CHD-APAH).Patients with invasively confirmed CHD-APAH received in-hospital exercise training for 3 weeks and continued at home. Efficacy parameters were evaluated at baseline, after 3 and 15 weeks. Medical treatment remained unchanged. Worsening events and survival rate were assessed in a follow-up period of 21 ± 14 months.Twenty consecutive CHD-APAH patients (16 female, 4 male, mean pulmonary arterial pressure 60 ± 23 mm Hg) were included. Patients significantly improved the mean distance walked in 6 min compared to baseline by 63 ± 47 m after 3 weeks (p<0.001) and by 67 ± 59 m after 15 weeks (p=0.001). Quality of life-score (p=0.05), peak oxygen consumption (p=0.002) and maximal workload (p=0.003) improved significantly by exercise training after 15 weeks. The 1- and 2-year survival rates were 100%, the transplantation-free survival rate was 100% after 1 year and 93% after 2 years.Exercise training as add-on to medical therapy may be effective in patients with CHD-APAH and improved work capacity, quality of life and further prognostic relevant parameters. It was associated with an excellent long-term survival. Further randomized controlled studies are needed to confirm these results.
Journal title abbreviation:: Int J Cardiol
Year:: 2013
Journal volume:: 168
Journal issue:: 1
Pages contribution:: 375-81
Language:: eng
Fulltext / DOI:: doi:10.1016/j.ijcard.2012.09.036
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/23041100
Print-ISSN:: 0167-5273
TUM Institution:: Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Kinderkardiologie und angeborene Herzfehler (DHM) (Prof. Ewert)2013