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Titel:

Innate immune response after adenoviral gene delivery into skin is mediated by AIM2, NALP3, DAI and mda5.

Dokumenttyp:
Journal Article
Autor(en):
Schulte, Matthias; Sorkin, Michael; Al-Benna, Sammy; Stupka, Jadwiga; Hirsch, Tobias; Daigeler, Adrien; Kesting, Marco Rainer; Steinau, Hans-Ulrich; Jacobsen, Frank; Steinstraesser, Lars
Abstract:
Methods for human skin gene therapy requires efficient and stable introduction of genes into skin cells. Transient cutaneous gene therapy is an attractive approach in the treatment of skin diseases. The 'Achilles heel' of adenoviral gene therapy is its immunogenicity and many aspects of adenovirus induced cutaneous immune reaction still remain unanswered, particularly the role of keratinocytes. Therefore, human keratinocytes were transfected with adenoviral DNA and cytokine expression was analyz...     »
Zeitschriftentitel:
Springerplus
Jahr:
2013
Band / Volume:
2
Heft / Issue:
1
Seitenangaben Beitrag:
234
Sprache:
eng
Volltext / DOI:
doi:10.1186/2193-1801-2-234
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23750330
Print-ISSN:
2193-1801
TUM Einrichtung:
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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