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Title:

YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Mantwill, Klaus; Naumann, Ulrike; Seznec, Janina; Girbinger, Vroni; Lage, Hermann; Surowiak, Pawel; Beier, Dagmar; Mittelbronn, Michel; Schlegel, Jürgen; Holm, Per Sonne
Abstract:
The brain cancer stem cell (CSC) model describes a small subset of glioma cells as being responsible for tumor initiation, conferring therapy resistance and tumor recurrence. In brain CSC, the PI3-K/AKT and the RAS/mitogen activated protein kinase (MAPK) pathways are found to be activated. In consequence, the human transcription factor YB-1, knowing to be responsible for the emergence of drug resistance and driving adenoviral replication, is phosphorylated and activated. With this knowledge, YB-...     »
Journal title abbreviation:
J Transl Med
Year:
2013
Journal volume:
11
Pages contribution:
216
Language:
eng
Fulltext / DOI:
doi:10.1186/1479-5876-11-216
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24044901
Print-ISSN:
1479-5876
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung
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