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Title:

Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Wagener, Jeanette; Malireddi, R K Subbarao; Lenardon, Megan D; Köberle, Martin; Vautier, Simon; MacCallum, Donna M; Biedermann, Tilo; Schaller, Martin; Netea, Mihai G; Kanneganti, Thirumala-Devi; Brown, Gordon D; Brown, Alistair J P; Gow, Neil A R
Abstract:
Chitin is an essential structural polysaccharide of fungal pathogens and parasites, but its role in human immune responses remains largely unknown. It is the second most abundant polysaccharide in nature after cellulose and its derivatives today are widely used for medical and industrial purposes. We analysed the immunological properties of purified chitin particles derived from the opportunistic human fungal pathogen Candida albicans, which led to the selective secretion of the anti-inflammator...     »
Journal title abbreviation:
PLoS Pathog
Year:
2014
Journal volume:
10
Journal issue:
4
Pages contribution:
e1004050
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.ppat.1004050
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24722226
Print-ISSN:
1553-7366
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie
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