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Titel:

An integrated epigenetic and transcriptomic analysis reveals distinct tissue-specific patterns of DNA methylation associated with atopic dermatitis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Rodriguez, Elke; Baurecht, Hansjörg; Wahn, Anna Franziska; Kretschmer, Anja; Hotze, Melanie; Zeilinger, Sonja; Klopp, Norman; Illig, Thomas; Schramm, Katharina; Prokisch, Holger; Kühnel, Brigitte; Gieger, Christian; Harder, Jürgen; Cifuentes, Liliana; Novak, Natalija; Weidinger, Stephan
Abstract:
Epigenetic alterations are increasingly recognized as mechanisms for disease-associated changes in genome function and important risk factors for complex diseases. The epigenome differs between cell types and so far has been characterized in few human tissues only. In order to identify disease-associated DNA methylation differences for atopic dermatitis (AD), we investigated DNA from whole blood, T cells, B cells, as well as lesional and non-lesional epidermis from AD patients and healthy contro...     »
Zeitschriftentitel:
J Invest Dermatol
Jahr:
2014
Band / Volume:
134
Heft / Issue:
7
Seitenangaben Beitrag:
1873-83
Sprache:
eng
Volltext / DOI:
doi:10.1038/jid.2014.87
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24739813
Print-ISSN:
0022-202X
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie
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