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Title:

An integrated epigenetic and transcriptomic analysis reveals distinct tissue-specific patterns of DNA methylation associated with atopic dermatitis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Rodriguez, Elke; Baurecht, Hansjörg; Wahn, Anna Franziska; Kretschmer, Anja; Hotze, Melanie; Zeilinger, Sonja; Klopp, Norman; Illig, Thomas; Schramm, Katharina; Prokisch, Holger; Kühnel, Brigitte; Gieger, Christian; Harder, Jürgen; Cifuentes, Liliana; Novak, Natalija; Weidinger, Stephan
Abstract:
Epigenetic alterations are increasingly recognized as mechanisms for disease-associated changes in genome function and important risk factors for complex diseases. The epigenome differs between cell types and so far has been characterized in few human tissues only. In order to identify disease-associated DNA methylation differences for atopic dermatitis (AD), we investigated DNA from whole blood, T cells, B cells, as well as lesional and non-lesional epidermis from AD patients and healthy contro...     »
Journal title abbreviation:
J Invest Dermatol
Year:
2014
Journal volume:
134
Journal issue:
7
Pages contribution:
1873-83
Language:
eng
Fulltext / DOI:
doi:10.1038/jid.2014.87
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24739813
Print-ISSN:
0022-202X
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie
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