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Title:

Adoptive immunotherapy: New assay for the identification of T cells with optimal avidity.

Document type:
Journal Article
Author(s):
Weissbrich, Bianca; Nauerth, Magdalena; Busch, Dirk H
Abstract:
T cells expressing high avidity T-cell receptors (TCRs) have been shown to mediate superior therapeutic effects. A novel koff-rate assay allows for the quantitative and reproducible assessment of the avidity of TCRs for their ligands directly on living T cells, ex vivo. This assay might facilitate the selection of T cells with an optimal avidity for their target, hence favoring the development of adoptive immunotherapeutic regimens.
Journal title abbreviation:
Oncoimmunology
Year:
2013
Journal volume:
2
Journal issue:
10
Pages contribution:
e26199
Language:
eng
Fulltext / DOI:
doi:10.4161/onci.26199
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24244903
Print-ISSN:
2162-4011
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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