Adoptive immunotherapy: New assay for the identification of T cells with optimal avidity.

Title:: Adoptive immunotherapy: New assay for the identification of T cells with optimal avidity.
Document type:: Journal Article
Author(s):: Weissbrich, Bianca; Nauerth, Magdalena; Busch, Dirk H
Abstract:: T cells expressing high avidity T-cell receptors (TCRs) have been shown to mediate superior therapeutic effects. A novel koff-rate assay allows for the quantitative and reproducible assessment of the avidity of TCRs for their ligands directly on living T cells, ex vivo. This assay might facilitate the selection of T cells with an optimal avidity for their target, hence favoring the development of adoptive immunotherapeutic regimens.
Journal title abbreviation:: Oncoimmunology
Year:: 2013
Journal volume:: 2
Journal issue:: 10
Pages contribution:: e26199
Language:: eng
Fulltext / DOI:: doi:10.4161/onci.26199
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/24244903
Print-ISSN:: 2162-4011
TUM Institution:: Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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