Benutzer: Gast  Login
Titel:

A novel therapeutic hepatitis B vaccine induces cellular and humoral immune responses and breaks tolerance in hepatitis B virus (HBV) transgenic mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Buchmann, P; Dembek, C; Kuklick, L; Jäger, C; Tedjokusumo, R; von Freyend, MJ; Drebber, U; Janowicz, Z; Melber, K; Protzer, U
Abstract:
Therapeutic vaccines are currently being developed for chronic hepatitis B and C. As an alternative to long-term antiviral treatment or to support only partially effective therapy, they should activate the patient's immune system effectively to fight and finally control the virus. A paradigm of therapeutic vaccination is the potent induction of T-cell responses against key viral antigens - besides activation of a humoral immune response. We have evaluated the potential of a novel vaccine formula...     »
Zeitschriftentitel:
Vaccine
Jahr:
2013
Band / Volume:
31
Heft / Issue:
8
Seitenangaben Beitrag:
1197-203
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.vaccine.2012.12.074
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23306359
Print-ISSN:
0264-410X
TUM Einrichtung:
Institut für Virologie
 BibTeX