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Dokumenttyp:
Journal Article; Article
Autor(en):
Kutscher, S; Dembek, CJ; Deckert, S; Russo, C; Körber, N; Bogner, JR; Geisler, F; Umgelter, A; Neuenhahn, M; Albrecht, J; Cosma, A; Protzer, U; Bauer, T
Titel:
Overnight Resting of PBMC Changes Functional Signatures of Antigen Specific T- Cell Responses: Impact for Immune Monitoring within Clinical Trials.
Abstract:
Polyfunctional CD4 or CD8 T cells are proposed to represent a correlate of immune control for persistent viruses as well as for vaccine mediated protection against infection. A well-suited methodology to study complex functional phenotypes of antiviral T cells is the combined staining of intracellular cytokines and phenotypic marker expression using polychromatic flow cytometry. In this study we analyzed the effect of an overnight resting period at 37°C on the quantity and functionality of HIV-1...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2013
Band / Volume:
8
Heft / Issue:
10
Seitenangaben Beitrag:
e76215
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0076215
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24146841
Print-ISSN:
1932-6203
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie
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