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Title:

A novel therapeutic hepatitis B vaccine induces cellular and humoral immune responses and breaks tolerance in hepatitis B virus (HBV) transgenic mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Buchmann, P; Dembek, C; Kuklick, L; Jäger, C; Tedjokusumo, R; von Freyend, MJ; Drebber, U; Janowicz, Z; Melber, K; Protzer, U
Abstract:
Therapeutic vaccines are currently being developed for chronic hepatitis B and C. As an alternative to long-term antiviral treatment or to support only partially effective therapy, they should activate the patient's immune system effectively to fight and finally control the virus. A paradigm of therapeutic vaccination is the potent induction of T-cell responses against key viral antigens - besides activation of a humoral immune response. We have evaluated the potential of a novel vaccine formula...     »
Journal title abbreviation:
Vaccine
Year:
2013
Journal volume:
31
Journal issue:
8
Pages contribution:
1197-203
Language:
eng
Fulltext / DOI:
doi:10.1016/j.vaccine.2012.12.074
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23306359
Print-ISSN:
0264-410X
TUM Institution:
Institut für Virologie
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