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Title:

RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation.

Document type:
Journal Article; Article
Author(s):
Vucur, M; Reisinger, F; Gautheron, J; Janssen, J; Roderburg, C; Cardenas, DV; Kreggenwinkel, K; Koppe, C; Hammerich, L; Hakem, R; Unger, K; Weber, A; Gassler, N; Luedde, M; Frey, N; Neumann, UP; Tacke, F; Trautwein, C; Heikenwalder, M; Luedde, T
Abstract:
For years, the term "apoptosis" was used synonymously with programmed cell death. However, it was recently discovered that receptor interacting protein 3 (RIP3)-dependent "necroptosis" represents an alternative programmed cell death pathway activated in many inflamed tissues. Here, we show in a genetic model of chronic hepatic inflammation that activation of RIP3 limits immune responses and compensatory proliferation of liver parenchymal cells (LPC) by inhibiting Caspase-8-dependent activation o...     »
Journal title abbreviation:
Cell Rep
Year:
2013
Journal volume:
4
Journal issue:
4
Pages contribution:
776-90
Language:
eng
Fulltext / DOI:
doi:10.1016/j.celrep.2013.07.035
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23972991
Print-ISSN:
2211-1247
TUM Institution:
Institut für Virologie
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