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Title:

Nonredundant function of soluble LT?3 produced by innate lymphoid cells in intestinal homeostasis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Kruglov, AA; Grivennikov, SI; Kuprash, DV; Winsauer, C; Prepens, S; Seleznik, GM; Eberl, G; Littman, DR; Heikenwalder, M; Tumanov, AV; Nedospasov, SA
Abstract:
Immunoglobulin A (IgA) production at mucosal surfaces contributes to protection against pathogens and controls intestinal microbiota composition. However, mechanisms regulating IgA induction are not completely defined. We show that soluble lymphotoxin ? (sLT?3) produced by ROR?t(+) innate lymphoid cells (ILCs) controls T cell-dependent IgA induction in the lamina propria via regulation of T cell homing to the gut. By contrast, membrane-bound lymphotoxin ? (LT?1?2) produced by ROR?t(+) ILCs is cr...     »
Journal title abbreviation:
Science
Year:
2013
Journal volume:
342
Journal issue:
6163
Pages contribution:
1243-6
Language:
eng
Fulltext / DOI:
doi:10.1126/science.1243364
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24311691
Print-ISSN:
0036-8075
TUM Institution:
Institut für Virologie
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