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Titel:

Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription.

Dokumenttyp:
Journal Article
Autor(en):
Benhenda, S; Ducroux, A; Rivière, L; Sobhian, B; Ward, MD; Dion, S; Hantz, O; Protzer, U; Michel, ML; Benkirane, M; Semmes, OJ; Buendia, MA; Neuveut, C
Abstract:
The hepatitis B virus X protein (HBx) is essential for virus replication and has been implicated in the development of liver cancer. HBx is recruited to viral and cellular promoters and activates transcription by interacting with transcription factors and coactivators. Here, we purified HBx-associated factors in nuclear extracts from HepG2 hepatoma cells and identified protein arginine methyltransferase 1 (PRMT1) as a novel HBx-interacting protein. We showed that PRMT1 overexpression reduced the...     »
Zeitschriftentitel:
J Virol
Jahr:
2013
Band / Volume:
87
Heft / Issue:
8
Seitenangaben Beitrag:
4360-71
Sprache:
eng
Volltext / DOI:
doi:10.1128/JVI.02574-12
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23388725
Print-ISSN:
0022-538X
TUM Einrichtung:
Institut für Virologie
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