Benutzer: Gast  Login
Titel:

Correlation of monoclonal and polyclonal somatostatin receptor 5 antibodies in pancreatic neuroendocrine tumors.

Dokumenttyp:
Journal Article
Autor(en):
Kaemmerer, D; Lupp, A; Peter, L; Fischer, E; Schulz, S; Klöppel, G; Hommann, M
Abstract:
To evaluate the frequency of somatostatin-receptor 5 (SSTR 5) in pancreatic neuroendocrine tumors by using monoclonal and polyclonal antibodies.we analyzed 66 proven pancreatic neuroendocrine tumors immunohistochemically with monoclonal (clone UMB-4) and polyclonal SSTR 5-antibodies. Immunoreactive score (IRS) and DAKO-score Her2/neu were evaluated.Immunohistochemistry analysis demonstrated for the IRS a significant higher staining of all specimen using the monoclonal antibodies ( IRS SSTR5 poly vs IRS SSTR 5 mono; 20.0% vs 30.3% p < 0.001) by a correlation of 0.21; p = 0.04. For the HER2 score there was also a significant higher staining in the monoclonal group (Her2 SSTR 5 poly vs Her2 SSTR 5 mono; 21.5% vs 28.8% p < 0.001) by a correlation of 0.20; p = 0.08.Both antibodies are useful in staining of SSTR, although UMB-4 demonstrated a 10% higher SSTR 5 staining. Due to the previous underestimated expression rate of SSTR 5, current standards in diagnostics and therapy should be reconsidered. The increasing usage of long-acting pansomatostatin receptor analogues will rise the adverse effects connected to SSTR5 binding.
Zeitschriftentitel:
Int J Clin Exp Pathol
Jahr:
2013
Band / Volume:
6
Heft / Issue:
1
Seitenangaben Beitrag:
49-54
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23236542
Print-ISSN:
1936-2625
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
 BibTeX