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Titel:

Restoration of sensitivity in chemo-resistant glioma cells by cold atmospheric plasma.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Köritzer, J; Boxhammer, V; Schafer, A; Shimizu, T; Klämpfl, TG; Li, YF; Welz, C; Schwenk-Zieger, S; Morfill, GE; Zimmermann, JL; Schlegel, J
Abstract:
Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. Despite multimodal treatments including surgery, chemotherapy and radiotherapy the prognosis remains poor and relapse occurs regularly. The alkylating agent temozolomide (TMZ) has been shown to improve the overall survival in patients with malignant gliomas, especially in tumors with methylated promoter of the O6-methylguanine-DNA-methyltransferase (MGMT) gene. However, intrinsic and acquired resistance towards TMZ makes...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2013
Band / Volume:
8
Heft / Issue:
5
Seitenangaben Beitrag:
e64498
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0064498
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23704990
Print-ISSN:
1932-6203
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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