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Titel:

Two decades of hepatitis B vaccination in mentally retarded patients: effectiveness, antibody persistence and duration of immune memory.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Braeckman, T; Van Herck, K; Jilg, W; Bauer, T; Van Damme, P
Abstract:
Institutionalized mentally retarded subjects are well-known to be at-risk for HBV infection. We studied the persistence of vaccine-induced anti-HBs antibodies and the robustness of the HBsAg-specific immune memory in this population, 18-20 years after the first vaccine dose.Non-immune residents of 4 institutions were immunized in 1984-1986. In 2004, 207 subjects were bled to determine humoral and cellular immune memory. Immune response to a booster dose was evaluated in subjects with anti-HBs level <100 IU/L.Four subjects showed anti-HBc seroconversion, without clinical implications. Pre-booster anti-HBs levels <100 IU/L were found in 45 subjects (22%); 34/39 (87%) responded with a rapid and high anti-HBs titer to the booster dose. Robust T and B cell memory was present pre- and post-booster.Overall results confirm that hepatitis B vaccines are highly effective and immunogenic, and confer long-term persistence of antibodies and immune memory in an at-risk population.
Zeitschriftentitel:
Vaccine
Jahr:
2012
Band / Volume:
30
Heft / Issue:
32
Seitenangaben Beitrag:
4757-61
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.vaccine.2012.05.044
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22652400
Print-ISSN:
0264-410X
TUM Einrichtung:
Institut für Virologie
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