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Title:

Accounting for biological variation in differential display two-dimensional electrophoresis experiments.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Valcu, CM; Reger, K; Ebner, J; Gorlach, A
Abstract:
Variation of protein expression levels was investigated in the heart, lung and liver from an inbred (C57/BL6) and an outbred (CD-1) mouse line. Based on the measured inter-individual variation, optimal sample sizes for two-dimensional electrophoresis experiments were determined by means of power analysis. For both lines, the level of protein expression variation was in the range of technical variation. Thus, although the differences in protein expression variation were significant between organs...     »
Journal title abbreviation:
J Proteomics
Year:
2012
Journal volume:
75
Journal issue:
12
Pages contribution:
3585-91
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jprot.2012.04.003
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22521271
Print-ISSN:
1874-3919
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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