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Title:

Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Wang, R; Kwon, IK; Thangaraju, M; Singh, N; Liu, K; Jay, P; Hofmann, F; Ganapathy, V; Browning, DD
Abstract:
Signaling through cGMP has emerged as an important regulator of tissue homeostasis in the gastrointestinal tract, but the mechanism is not known. Type 2 cGMP-dependent protein kinase (PKG2) is a major cGMP effector in the gut epithelium, and the present studies have tested its importance in the regulation of proliferation and differentiation in the mouse colon and in colon cancer cell lines. Tissue homeostasis was examined in the proximal colon of Prkg2(-/-) mice using histological markers of pr...     »
Journal title abbreviation:
Am J Physiol Gastrointest Liver Physiol
Year:
2012
Journal volume:
303
Journal issue:
2
Pages contribution:
G209-19
Language:
eng
Fulltext / DOI:
doi:10.1152/ajpgi.00500.2011
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22556146
Print-ISSN:
0193-1857
TUM Institution:
Institut für Pharmakologie und Toxikologie
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