Benutzer: Gast  Login
Titel:

Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial node.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Article
Autor(en):
Christel, CJ; Cardona, N; Mesirca, P; Herrmann, S; Hofmann, F; Striessnig, J; Ludwig, A; Mangoni, ME; Lee, A
Abstract:
Dysregulation of L-type Ca(2+) currents in sinoatrial nodal (SAN) cells causes cardiac arrhythmia. Both Ca(v)1.2 and Ca(v)1.3 channels mediate sinoatrial L-type currents. Whether these channels exhibit differences in modulation and localization, which could affect their contribution to pacemaking, is unknown. In this study, we characterized voltage-dependent facilitation (VDF) and subcellular localization of Ca(v)1.2 and Ca(v)1.3 channels in mouse SAN cells and determined how these properties of...     »
Zeitschriftentitel:
J Physiol
Jahr:
2012
Band / Volume:
590
Heft / Issue:
Pt 24
Seitenangaben Beitrag:
6327-42
Sprache:
eng
Volltext / DOI:
doi:10.1113/jphysiol.2012.239954
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23045342
Print-ISSN:
0022-3751
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
 BibTeX