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Title:

The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Ziegler, M; Elvers, M; Baumer, Y; Leder, C; Ochmann, C; Schonberger, T; Jürgens, T; Geisler, T; Schlosshauer, B; Lunov, O; Engelhardt, S; Simmet, T; Gawaz, M
Abstract:
CXCR4-positive bone marrow cells (BMCs) are critically involved in cardiac repair mechanisms contributing to preserved cardiac function. Stromal cell-derived factor-1 (SDF-1) is the most prominent BMC homing factor known to augment BMC engraftment, which is a limiting step of stem cell-based therapy. After myocardial infarction, SDF-1 expression is rapidly upregulated and promotes myocardial repair.We have established a bifunctional protein consisting of an SDF-1 domain and a glycoprotein VI (GP...     »
Journal title abbreviation:
Circulation
Year:
2012
Journal volume:
125
Journal issue:
5
Pages contribution:
685-96
Language:
eng
Fulltext / DOI:
doi:10.1161/CIRCULATIONAHA.111.070508
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22223428
Print-ISSN:
0009-7322
TUM Institution:
Institut für Pharmakologie und Toxikologie
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