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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Brandmayr, J; Poomvanicha, M; Domes, K; Ding, J; Blaich, A; Wegener, JW; Moosmang, S; Hofmann, F
Titel:
Deletion of the C-terminal phosphorylation sites in the cardiac ?-subunit does not affect the basic ?-adrenergic response of the heart and the Ca(v)1.2 channel.
Abstract:
Phosphorylation of the cardiac ? subunit (Ca(v)?(2)) of the Ca(v)1.2 L-type Ca(2+) channel complex has been proposed as a mechanism for regulation of L-type Ca(2+) channels by various protein kinases including PKA, CaMKII, Akt/PKB, and PKG. To test this hypothesis directly in vivo, we generated a knock-in mouse line with targeted mutation of the Ca(v)?(2) gene by insertion of a stop codon after proline 501 in exon 14 (mouse sequence Cacnb2; ?Stop mouse). This mutation prevented translation of t...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2012
Band / Volume:
287
Heft / Issue:
27
Seitenangaben Beitrag:
22584-92
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.M112.366484
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22589548
Print-ISSN:
0021-9258
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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