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Title:

Ca(v)1.3 L-type Ca2+ channels mediate long-term adaptation in dopamine D2L-mediated GluA1 trafficking in the dorsal striatum following cocaine exposure

Document type:
Article
Author(s):
Schierberl, K; Giordano, T; Satpute, S; Hao, J; Kaur, G; Hofmann, F; Moosmang, S; Striessnig, J; Rajadhyaksha, A
Abstract:
AMPA receptor (AMPAR) plasticity at glutamatergic synapses in the mesostriatal dopaminergic pathway has been implicated in persistent cocaine-induced behavioral responses; however, the precise mechanism underlying these changes remains unknown. Utilizing cocaine psychomotor sensitization in mice we find that repeated cocaine results in a basal reduction of Ser 845 GluA1 and cell surface GluA1 levels in the dorsal striatum (dStr) following a protracted withdrawal period, an adaptation that is de...     »
Journal title abbreviation:
Channels
Year:
2012
Journal volume:
6
Journal issue:
1
Pages contribution:
11-17
Language:
eng
Print-ISSN:
0009-1510
TUM Institution:
Institut für Pharmakologie und Toxikologie
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