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Titel:

Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Wang, R; Kwon, IK; Thangaraju, M; Singh, N; Liu, K; Jay, P; Hofmann, F; Ganapathy, V; Browning, DD
Abstract:
Signaling through cGMP has emerged as an important regulator of tissue homeostasis in the gastrointestinal tract, but the mechanism is not known. Type 2 cGMP-dependent protein kinase (PKG2) is a major cGMP effector in the gut epithelium, and the present studies have tested its importance in the regulation of proliferation and differentiation in the mouse colon and in colon cancer cell lines. Tissue homeostasis was examined in the proximal colon of Prkg2(-/-) mice using histological markers of pr...     »
Zeitschriftentitel:
Am J Physiol Gastrointest Liver Physiol
Jahr:
2012
Band / Volume:
303
Heft / Issue:
2
Seitenangaben Beitrag:
G209-19
Sprache:
eng
Volltext / DOI:
doi:10.1152/ajpgi.00500.2011
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22556146
Print-ISSN:
0193-1857
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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