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Titel:

cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis.

Dokumenttyp:
Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural; Article
Autor(en):
Shimizu-Albergine, M; Tsai, LC; Patrucco, E; Beavo, JA
Abstract:
Phosphodiesterase (PDE) 8A and PDE8B are high-affinity, cAMP-specific phosphodiesterases that are highly expressed in Leydig cells. PDE8A is largely associated with mitochondria, whereas PDE8B is broadly distributed in the cytosol. We used a new, PDE8-selective inhibitor, PF-04957325, and genetically ablated PDE8A(-/-), PDE8B(-/-) and PDE8A(-/-)/B(-/-) mice to determine roles for these PDEs in the regulation of testosterone production. PF-04957325 treatment of WT Leydig cells or MA10 cells incre...     »
Zeitschriftentitel:
Mol Pharmacol
Jahr:
2012
Band / Volume:
81
Heft / Issue:
4
Seitenangaben Beitrag:
556-66
Sprache:
eng
Volltext / DOI:
doi:10.1124/mol.111.076125
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22232524
Print-ISSN:
0026-895X
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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