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Titel:

TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Oldenburg, M; Kruger, A; Ferstl, R; Kaufmann, A; Nees, G; Sigmund, A; Bathke, B; Lauterbach, H; Suter, M; Dreher, S; Koedel, U; Akira, S; Kawai, T; Buer, J; Wagner, H; Bauer, S; Hochrein, H; Kirschning, CJ
Abstract:
Host protection from infection relies on the recognition of pathogens by innate pattern-recognition receptors such as Toll-like receptors (TLRs). Here, we show that the orphan receptor TLR13 in mice recognizes a conserved 23S ribosomal RNA (rRNA) sequence that is the binding site of macrolide, lincosamide, and streptogramin group (MLS) antibiotics (including erythromycin) in bacteria. Notably, 23S rRNA from clinical isolates of erythromycin-resistant Staphylococcus aureus and synthetic oligoribo...     »
Zeitschriftentitel:
Science
Jahr:
2012
Band / Volume:
337
Heft / Issue:
6098
Seitenangaben Beitrag:
1111-5
Sprache:
eng
Volltext / DOI:
doi:10.1126/science.1220363
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22821982
Print-ISSN:
0036-8075
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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