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Titel:

MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Wernicke, CM; Richter, GH; Beinvogl, BC; Plehm, S; Schlitter, AM; Bandapalli, OR; Prazeres da Costa, O; Hattenhorst, UE; Volkmer, I; Staege, MS; Esposito, I; Burdach, S; Grunewald, TG
Abstract:
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted therapy, we performed a comprehensive transcriptome analysis identifying MondoA (MLXIP) - a transcription factor regulating glycolysis - to be overexpressed in ALL compared to normal tissues. Using microarray-profiling, gene-set enrichment analysis, RNA interference and functional assays we show that MondoA overexpression increases glucose catabolism and maintains a more immature phe...     »
Zeitschriftentitel:
Leuk Res
Jahr:
2012
Band / Volume:
36
Heft / Issue:
9
Seitenangaben Beitrag:
1185-92
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.leukres.2012.05.009
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22748921
Print-ISSN:
0145-2126
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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