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Titel:

Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice.

Dokumenttyp:
Journal Article
Autor(en):
Stross, L; Gunther, J; Gasteiger, G; Asen, T; Graf, S; Aichler, M; Esposito, I; Busch, DH; Knolle, P; Sparwasser, T; Protzer, U
Abstract:
The strength of antiviral T cell responses correlates with clearance of hepatitis B virus (HBV) infection, but the immunological mechanisms mitigating or suppressing HBV-specific T cells are still poorly understood. In this study, we examined the role of CD4(+) Foxp3(+) regulatory T cells (Tregs) in a mouse model of acute HBV infection. We initiated HBV infection via an adenoviral vector transferring a 1.3-fold overlength HBV genome (AdHBV) into transgenic DEREG mice, where Tregs can be transien...     »
Zeitschriftentitel:
Hepatology
Jahr:
2012
Band / Volume:
56
Heft / Issue:
3
Seitenangaben Beitrag:
873-83
Sprache:
eng
Volltext / DOI:
doi:10.1002/hep.25765
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22487943
Print-ISSN:
0270-9139
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie
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