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Titel:

Pre-existing virus-specific CD8(+) T-cells provide protection against pneumovirus-induced disease in mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
van Helden, MJ; van Kooten, PJ; Bekker, CP; Gröne, A; Topham, DJ; Easton, AJ; Boog, CJ; Busch, DH; Zaiss, DM; Sijts, AJ
Abstract:
Pneumoviruses such as pneumonia virus of mice (PVM), bovine respiratory syncytial virus (bRSV) or human (h)RSV are closely related pneumoviruses that cause severe respiratory disease in their respective hosts. It is well-known that T-cell responses are essential in pneumovirus clearance, but pneumovirus-specific T-cell responses also are important mediators of severe immunopathology. In this study we determined whether memory- or pre-existing, transferred virus-specific CD8(+) T-cells provide pr...     »
Zeitschriftentitel:
Vaccine
Jahr:
2012
Band / Volume:
30
Heft / Issue:
45
Seitenangaben Beitrag:
6382-8
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.vaccine.2012.08.027
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22940382
Print-ISSN:
0264-410X
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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