Benutzer: Gast  Login
Weniger Felder
Einfache Suche
Titel:

Prolyl hydroxylase-2 (PHD2) exerts tumor-suppressive activity in pancreatic cancer.

Dokumenttyp:
Journal Article
Autor(en):
Su, Y; Loos, M; Giese, N; Metzen, E; Büchler, MW; Friess, H; Kornberg, A; Büchler, P
Abstract:
Pancreatic cancer is 1 of the most common and poorly treated tumors. In search of new therapeutic approaches, the oxygen sensors prolyl hydroxylases (PHD) are potential targets. PHD2 is considered the key oxygen sensor-regulating hypoxia-inducible factor (HIF). Currently, there is conflicting evidence regarding the exact role of PHD2 in tumorigenesis. The objective of this study was to investigate the role of PHD2 in pancreatic cancer growth and progression.PHD2 expression was analyzed by quanti...     »
Zeitschriftentitel:
Cancer
Jahr:
2012
Band / Volume:
118
Heft / Issue:
4
Seitenangaben Beitrag:
960-72
Sprache:
eng
Volltext / DOI:
doi:10.1002/cncr.26344
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21792862
Print-ISSN:
0008-543X
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
 BibTeX