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Titel:

Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Zhang, D; Dong, P; Zhang, K; Deng, L; Bach, C; Chen, W; Li, F; Protzer, U; Ding, H; Zeng, C
Abstract:
Hepatitis B virus (HBV), because of its error-prone viral polymerase, has a high mutation rate leading to widespread substitutions, deletions, and insertions in the HBV genome. Deletions may significantly change viral biological features complicating the progression of liver diseases. However, the clinical conditions correlating to the accumulation of deleted mutants remain unclear. In this study, we explored HBV deletion patterns and their association with disease status and antiviral treatment...     »
Zeitschriftentitel:
BMC Microbiol
Jahr:
2012
Band / Volume:
12
Seitenangaben Beitrag:
307
Sprache:
eng
Volltext / DOI:
doi:10.1186/1471-2180-12-307
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23272650
Print-ISSN:
1471-2180
TUM Einrichtung:
Institut für Virologie
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