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Titel:

HIV-mediated up-regulation of invariant chain (CD74) correlates with generalized immune activation in HIV+ subjects.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Ghiglione, Y; Rodríguez, AM; De Candia, C; Carobene, M; Benaroch, P; Schindler, M; Salomón, H; Turk, G
Abstract:
HIV Nef-mediated up-regulation of invariant chain (Ii chain, also CD74) is presumed to play an active role in HIV immunopathogenesis. However, this has not been definitely ascertained. In order to help elucidate this hypothesis, Ii chain, CD4, HLA-DR and HLA-ABC expression was analyzed ex vivo in monocyte-derived macrophages (MDMs) from HIV(+) subjects. Viral load, CD4(+) T cell count and immune activation were also determined in enrolled subjects. Correlations between these parameters and the m...     »
Zeitschriftentitel:
Virus Res
Jahr:
2012
Band / Volume:
163
Heft / Issue:
1
Seitenangaben Beitrag:
380-4
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.virusres.2011.09.011
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21945129
Print-ISSN:
0168-1702
TUM Einrichtung:
Institut für Virologie
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