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Title:

TNF-induced target cell killing by CTL activated through cross-presentation.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Journal Article
Author(s):
Wohlleber, D; Kashkar, H; Gärtner, K; Frings, MK; Odenthal, M; Hegenbarth, S; Borner, C; Arnold, B; Hämmerling, G; Nieswandt, B; van Rooijen, N; Limmer, A; Cederbrant, K; Heikenwalder, M; Pasparakis, M; Protzer, U; Dienes, HP; Kurts, C; Krönke, M; Knolle, PA
Abstract:
Viruses can escape cytotoxic T cell (CTL) immunity by avoiding presentation of viral components via endogenous MHC class I antigen presentation in infected cells. Cross-priming of viral antigens circumvents such immune escape by allowing noninfected dendritic cells to activate virus-specific CTLs, but they remain ineffective against infected cells in which immune escape is functional. Here, we show that cross-presentation of antigen released from adenovirus-infected hepatocytes by liver sinusoid...     »
Journal title abbreviation:
Cell Rep
Year:
2012
Journal volume:
2
Journal issue:
3
Pages contribution:
478-87
Language:
eng
Fulltext / DOI:
doi:10.1016/j.celrep.2012.08.001
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22939982
Print-ISSN:
2211-1247
TUM Institution:
Institut für Virologie
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