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Titel:

Nucleic acids from long-term preserved FFPE tissues are suitable for downstream analyses.

Dokumenttyp:
Journal Article
Autor(en):
Ludyga, N; Grünwald, B; Azimzadeh, O; Englert, S; Höfler, H; Tapio, S; Aubele, M
Abstract:
Tissues used for clinical diagnostics are mostly formalin-fixed and paraffin-embedded (FFPE) which provides many advantages. However, the quality of the obtained nucleic acids (NA) is reduced and this turns out to be a challenge for further molecular analyses. Although the spectrum of analyses of NA extracted from FFPE tissue has increased, the standard operating procedures for NA isolation from old tissue blocks still need to be improved. Here, we compared the efficiency of different NA extract...     »
Zeitschriftentitel:
Virchows Arch
Jahr:
2012
Band / Volume:
460
Heft / Issue:
2
Seitenangaben Beitrag:
131-40
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00428-011-1184-9
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22270699
Print-ISSN:
0945-6317
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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