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Titel:

Effects of cold ischemia and inflammatory tumor microenvironment on detection of PI3K/AKT and MAPK pathway activation patterns in clinical cancer samples.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Bonnas, C; Specht, K; Spleiss, O; Froehner, S; Dietmann, G; Krüger, JM; Arbogast, S; Feuerhake, F
Abstract:
The accuracy of common markers for PI3K/AKT and MAPK pathway activation in preclinical and clinical cancer biomarker studies depends on phosphoepitope stability and changes of phosphorylation under ischemia. Herein, we define conditions under which phosphoepitope-specific duplex immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded tumor tissues reflects pathway activation in situ as accurately as possible, and identify activation patterns linked to mutational status, pathway dependenc...     »
Zeitschriftentitel:
Int J Cancer
Jahr:
2012
Band / Volume:
131
Heft / Issue:
7
Seitenangaben Beitrag:
1621-32
Sprache:
eng
Volltext / DOI:
doi:10.1002/ijc.27422
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22213219
Print-ISSN:
0020-7136
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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