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Title:

IgG glycan hydrolysis by EndoS inhibits experimental autoimmune encephalomyelitis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Benkhoucha, M; Molnarfi, N; Santiago-Raber, ML; Weber, MS; Merkler, D; Collin, M; Lalive, PH
Abstract:
Studies in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, have shown that B cells markedly influence the course of the disease, although whether their effects are protective or pathological is a matter of debate. EndoS hydrolysis of the IgG glycan has profound effects on IgG effector functions, such as complement activation and Fc receptor binding, suggesting that the enzyme could be used as an immunomodulatory therapeutic agent against IgG-mediated disease...     »
Journal title abbreviation:
J Neuroinflammation
Year:
2012
Journal volume:
9
Pages contribution:
209
Language:
eng
Fulltext / DOI:
doi:10.1186/1742-2094-9-209
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22943418
Print-ISSN:
1742-2094
TUM Institution:
Neurologische Klinik und Poliklinik
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