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Title:

Disability outcome measures in multiple sclerosis clinical trials: current status and future prospects.

Document type:
journal article
Author(s):
Cohen, JA; Reingold, SC; Polman, CH; Wolinsky, JS; International Advisory Committee on Clinical Trials in Multiple Sclerosis; Polman, CH; Barkhof, F; Balcer, LJ; Banwell, B; Calabresi, P; Clanet, M; Cohen, JA; Comi, G; Cutter, GR; Freedman, MS; Goodman, AD; Kappos, L; Kieseier, BC; Lubetzki, C; Lublin, FD; Miller, A; Montalban, X; O'Connor, P; Petkau, J; Pozzilli, C; Reingold, SC; Sørensen, PS; Sormani, MP; Stuve, O; Thompson, AJ; Wolinsky, JS
Abstract:
Many of the available disability outcome measures used in clinical trials of multiple sclerosis are insensitive to change over time, inadequately validated, or insensitive to patient-perceived health status or quality of life. Increasing focus on therapies that slow or reverse disability progression makes it essential to refine existing measures or to develop new tools. Major changes to the expanded disability status scale should be avoided to prevent the loss of acceptance by regulators as a me...     »
Journal title abbreviation:
Lancet Neurol
Year:
2012
Journal volume:
11
Journal issue:
5
Pages contribution:
467-76
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22516081
Print-ISSN:
1474-4422
TUM Institution:
Neurologische Klinik und Poliklinik
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